Hyaluronic Acid CAS 9004-61-9

Hyaluronic Acid – Natural Polysaccharide for Moisturization, Joint Health, and Tissue Regeneration

Basic Information

• CAS Number: 9004-61-9

• Molecular Formula: (C₁₄H₂₁NO₁₁)ₙ

• Appearance: White amorphous powder or fibrous mass, odorless

• Solubility: Swells and dissolves in water, forming highly viscous solutions; insoluble in most organic solvents

• Storage: Store in tightly sealed containers in a cool, dry place, protected from moisture and direct sunlight

• Stability: Sensitive to extreme pH and high temperatures; may degrade in acidic conditions (pH < 3) or during autoclaving

Overview
Hyaluronic acid (also known as hyaluronan) is a naturally occurring glycosaminoglycan composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine. It is widely distributed in connective, epithelial, and neural tissues in mammals, where it plays a crucial role in tissue hydration, lubrication, and cellular function. Its unique ability to bind and retain large amounts of water makes it a valuable ingredient in cosmetics, medicine, and tissue engineering.

Applications

• Medicine: Used in intra‑articular injections for osteoarthritis, wound healing dressings, ophthalmic solutions (eye drops and gels), and as an adhesion barrier in surgery.

• Cosmetics and skincare: Incorporated into moisturizers, serums, face creams, and dermal fillers to improve skin hydration, elasticity, and texture.

• Tissue engineering: Serves as a biocompatible scaffold for cell culture and regenerative medicine applications.

• Nutraceuticals: Available as a dietary supplement for joint health and skin hydration.

Key Benefits

• Exceptional water‑binding capacity – can retain up to 1,000 times its weight in water.

• Provides long‑lasting hydration and improves skin elasticity.

• Lubricates joints and supports cartilage health.

• Biocompatible and biodegradable.

• Well‑tolerated with low risk of allergic reactions.

• Available in various molecular weights for tailored applications.

Safety and Handling

• Generally recognized as safe (GRAS) for use in cosmetics and food supplements.

• Avoid exposure to strong acids, bases, and high temperatures (>60°C) to prevent degradation.

• Use appropriate personal protective equipment (gloves, dust mask) when handling.

• Shelf life: typically 24 months under recommended storage conditions.

Quality Assurance
Each batch is tested for purity, molecular weight, and microbial contamination to ensure consistent quality.