Phenylethyl Resorcinol - CAS 85-27-8

Phenylethyl Resorcinol (CAS 85-27-8): Overview

1. Chemical Description

Phenylethyl resorcinol belongs to the alkylresorcinol class, where substitution occurs at position 4 of resorcinol. This structure determines its ability to effectively inhibit melanin synthesis and maintain stability in cosmetic formulations.

2. Synonyms and Variant Names

• Primary: Phenylethyl Resorcinol

• Additional: Phenylethyl Resorcinol, SymWhite® 377

• Chemical: 4-(1-Phenylethyl)-1,3-benzenediol

3. Properties and Characteristics

Molecular formula: C₁₄H₁₄O₂

Appearance: White crystalline powder.

Odor: Odorless or very faint.

Density: ~1.18 g/cm³ (20°C).

Melting point: Typically in the range of 78–82°C.

Solubility: Limited solubility in water; readily soluble in alcohols and glycols; adequately dispersible in emulsion bases.

Storage conditions: Airtight containers, cool and dark place; avoid humidity fluctuations and direct sunlight.

Stability: Oxidation resistance is higher than that of many other phenols, but improper storage may cause product darkening.

4. Biological Effects

Primary action: Depigmenting effect by reducing the activity of enzymes responsible for melanogenesis.

Additional effects: Antioxidant properties; improvement of overall skin condition when used in combination with other actives (retinol, niacinamide).

Safety: Generally well-tolerated at concentrations up to 1%. Exceeding the dose may cause irritation and increased photosensitivity.

5. Areas of Application

Cosmetics: Brightening creams, anti-aging products, serums for hyperpigmentation.

Medical developments: Formulations for local treatment of hyperpigmentation, including melasma, lentigo, and post-acne marks.

Research and development: Creation of new combination depigmenting complexes based on phenylethyl resorcinol.

6. Conclusion

Due to its high efficacy and relatively mild effect on the skin, phenylethyl resorcinol (CAS 85-27-8) occupies a significant place among modern brightening ingredients. Its stability in cosmetic formulations and synergy with other actives allow achieving results in evening skin tone and combating hyperpigmentation. However, careful attention to dosage and storage is essential to avoid side effects and maintain the activity of the substance.