3-O-Ethyl-L-ascorbic acid - Ethyl Ascorbic Acid CAS 86404-04-8

3-O-Ethyl-L-ascorbic acid (CAS 86404-04-8): Overview

1. General Characteristics

3-O-Ethyl-L-ascorbic acid is a semi-synthetic ether of vitamin C obtained by esterification of the hydroxyl group. This modification provides enhanced stability compared to classical forms of ascorbic acid, especially upon contact with air and light.

2. Synonyms and Variant Names

• Russian: 3-О-этил-L-аскорбиновая кислота

• English: 3-O-Ethyl-L-ascorbic acid, Ethyl Ascorbic Acid

• German: 3-O-Ethyl-L-Ascorbinsäure

3. Chemical and Physical Properties

Molecular formula: C₈H₁₂O₆

Appearance: White crystalline powder.

Odor: Close to neutral, with a slightly acidic note.

Density: Approximately 1.65 g/cm³.

Melting point: In the range of 110–115°C.

Solubility: Water-soluble; readily soluble in alcohols (ethanol); poorly soluble in oils and non-polar hydrocarbons.

Decomposition: Subject to breakdown upon contact with metal oxidation catalysts (iron, copper); loses active properties at high temperatures.

4. Effects on Skin and Body

Biological effects are due to antioxidant action of the reducing type and participation in collagen synthesis. Due to these properties, the substance is widely used in anti-aging, whitening, and photoprotection formulations.

5. Applications

Cosmetic industry: Widely used in serums, emulsions, masks, and premium creams due to stability and effective delivery of vitamin C to the skin.

Pharmaceutical preparations: May be added to certain dosage forms aimed at enhancing immunity and tissue regeneration for topical or oral use.

Research and development: Includes studies of more stable analogues of traditional vitamins to external influences.

6. Storage Conditions and Precautions

Store in sealed packaging at temperatures from 5 to 25°C. Avoid prolonged contact with light and air to prevent loss of effectiveness. In cosmetic formulations, it is often combined with chelating agents (e.g., EDTA) and antioxidants (tocopherol) to reduce the risk of oxidation.

7. Conclusion

3-O-Ethyl-L-ascorbic acid (CAS 86404-04-8) is one of the most promising forms of vitamin C for cosmetic and pharmaceutical products, combining high antioxidant activity and stability to external factors. Its application helps effectively combat hyperpigmentation, stimulate collagen synthesis, and protect the skin from free radicals.